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Article

Variable frequency of LRRK2 variants in the Latin American research consortium on the genetics of Parkinson’s disease (LARGE-PD), a case of ancestry

26 May 2017

Abstract excerpt

Abstract Mutations in Leucine Repeat Rich Kinase 2 (LRRK2) , primarily located in codons G2019 and R1441, represent the most common genetic cause of Parkinson’s disease in European-derived populations. However, little is known about the frequency of these mutations in Latin American populations. In addition, a prior study suggested that a LRRK2 polymorphism (p.Q1111H) specific to Latino and Amerindian populations...

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Identifiers

PMID: 28649619
DOI: 10.1038/s41531-017-0020-6

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