Article
LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance.
Archives of neurology - 1 Mar 2006
Gaig Carles, Ezquerra Mario, Marti Maria Jose, Muñoz Esteban, Valldeoriola Francesc, Tolosa Eduardo
Abstract excerpt
BACKGROUND: Several pathogenic mutations in the LRRK2 gene have been implicated in familial and sporadic cases of Parkinson disease (PD). The R1441G mutation is frequent in Spanish patients of Basque ethnicity with PD, and the G2019S mutation is a common mutation found in several populations worl...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Arginine
- Child
- Child, Preschool
- DNA Mutational Analysis
- Family Health
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Glycine
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged