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Article

Epigenetic asymmetry in the zygote and mammalian development

1 Jan 2009

Abstract excerpt

In mammals, the maternal and the paternal genome are not functionally equivalent and are both required for embryonic and postnatal development. The genome is organised differently in the oocyte as compared to sperm, in which the DNA is tightly packaged with protamines rather than with histones. The requirement of both the parental genomes for normal development is a consequence of differential epigenetic marking...

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PMID: 19378254
DOI: 10.1387/ijdb.082654rf

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