Article
Epigenetic and replacement roles of histone variant H3.3 in reproduction and development.
The International journal of developmental biology - 1 Jan 2009
Orsi Guillermo A, Couble Pierre, Loppin Benjamin
Abstract excerpt
The nucleosomal organization of eukaryotic chromatin is generally established during DNA replication by the deposition of canonical histones synthesized in S phase. However, cells also use a Replication Independent (RI) nucleosome assembly pathway that allows the incorporation of non-canonical histone variants in the chromatin. H3.3 is a conserved histone variant that is structurally very close to its canonical...
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