Article
Exchanges of histone methylation and variants during mouse zygotic genome activation.
Zygote (Cambridge, England) - 1 Feb 2020
Deng Mingtian, Chen Baobao, Liu Zifei, Cai Yu, Wan Yongjie, Zhou Jianguo, Wang Feng
Abstract excerpt
Minor and major zygotic genome activation (ZGA) are crucial for preimplantation development. During this process, histone variants and methylation influence chromatin accessibility and consequently regulated the expression of zygotic genes. However, the detailed exchanges of these modifications during ZGA remain to be determined. In the present study, the epigenetic modifications of histone 3 on lysine 9 (H3K9),...
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