Interactions among polymorphic and conserved residues in MHC class II proteins affect MHC-peptide conformation and T cell recognition.

doi:10.1093/intimm/7.5.747

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Article

Interactions among polymorphic and conserved residues in MHC class II proteins affect MHC-peptide conformation and T cell recognition.

International immunology - 1 May 1995

Tate K M, Lee C, Edelman S, Carswell-Crumpton C, Liblau R, Jones P P

Abstract excerpt

The structural basis for MHC-restricted T cell recognition of the N-terminal peptide of myelin basic protein (MBP Ac1-11) presented by two mouse class II alleles, Ak and Au, was examined, focusing on the roles of A beta chain polymorphic residues 38 beta (in the beta sheet) and 61 beta (in the alpha helix) in controlling the responses of panels of Ak- and Au-restricted T cell hybridomas. Despite the conservative...

Topics

Alleles
Amino Acid Sequence
Animals
Antigen Presentation
Base Sequence
HLA-DR1 Antigen
Humans
Hybridomas
Mice
Models, Structural
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Site-Directed

Myelin Basic Protein

Peptides

Polymorphism, Genetic

Protein Binding

Protein Conformation

Rats

Source

Open in PubMed

Identifiers

PMID: 7547702
DOI: 10.1093/intimm/7.5.747

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7547702-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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