Article
Li-Fraumeni syndrome: a p53 family affair.
Cell cycle (Georgetown, Tex.) - 1 Jul 2005
Iwakuma Tomoo, Lozano Guillermina, Flores Elsa R
Abstract excerpt
The p53 alterations frequently found in human tumors are missense mutations in the DNA binding domain. These p53 mutations have been shown to have gain-of-function or dominant-negative properties in multiple experiments. The consequences of these p53 mutations at physiological levels on the development of a tumor were unclear. Using mouse models, three recent papers have shed light on the mechanisms of mutant p53...
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