Crippling p53 activities via knock-in mutations in mouse models.

Abstract excerpt

The tumor suppressor p53 is the most frequently mutated gene in human cancer. In vivo models have been generated using knock-in alleles in which missense mutations are introduced that mimic the kinds of mutations found in human cancers, or that abolish specific p53 functions. Critically, these studies examine the in vivo and physiological functions of p53. Studies indicate that p53 missense mutations in the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Cell Cycle
• Share to Mice, Transgenic