Article
The Li-Fraumeni syndrome: an inherited susceptibility to cancer.
Molecular medicine today - 1 Sept 1997
Evans S C, Lozano G
Abstract excerpt
The Li-Fraumeni syndrome is a rare autosomal-dominant disease whose hallmark is a predisposition to a wide range of cancers among members of a family. Many of these families have a germline mutation within the tumor suppressor gene TP53, which encodes the p53 protein. The inheritance of a mutant TP53 allele results in a 25-fold increase in the chance of developing cancer by 50 years of age, compared with the...
Topics
- Cell Cycle
- Chromosomes, Human, Pair 17
- Female
- Genes, Dominant
- Genes, p53
- Genetic Predisposition to Disease
- Genetic Testing
- Germ-Line Mutation
- Humans
- Li-Fraumeni Syndrome
- Male
- Pedigree
- Tumor Suppressor Protein p53