Article
Contribution of p53, p63, and p73 to the developmental diseases and cancer.
Neoplasma - 1 Jan 2008
Tomkova K, Tomka M, Zajac V
Abstract excerpt
Tumor suppressor TP53 gene is one of the most mutated genes in human genome. Inactivating somatic mutations and disruption of p53 protein have been described in almost all human malignancies. Its inactivation by germline mutation leads to the rare but severe familial precancerosis termed Li-Fraumeni syndrome. This syndrome is characterized by the early onset of different types of cancers including soft-tissue...
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