Article
Analysing p53 tumour suppressor functions in mice.
Expert opinion on therapeutic targets - 1 Feb 2003
Sluss Hayla K, Jones Stephen N
Abstract excerpt
Loss of tumour suppressor function is a common mechanistic step in deregulated cell growth and neoplasia. The p53 tumour suppressor gene is the most frequently mutated gene in cancer, and is inactivated in approximately 50% of human tumours. Mutation of p53 is also the predominant molecular basis of the Li-Fraumeni familial cancer susceptibility syndrome. p53 is a transcription factor that functions to regulate...
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