Article
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome.
Cell - 17 Dec 2004
Olive Kenneth P, Tuveson David A, Ruhe Zachary C, Yin Bob, Willis Nicholas A, Bronson Roderick T, Crowley Denise, Jacks Tyler
Abstract excerpt
The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of-function properties to p53. To ascertain the physiological effects of p53 point mutation, the structural mutant p53R172H and the contact mutant p53R270H (codons 175 and 273 in humans) were engineered...
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