Article
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family.
Cancer cell - 1 Apr 2005
Flores Elsa R, Sengupta Shomit, Miller John B, Newman Jamie J, Bronson Roderick, Crowley Denise, Yang Annie, McKeon Frank, Jacks Tyler
Abstract excerpt
p63 and p73 are functionally and structurally related to the tumor suppressor p53. However, their own role in tumor suppression is unclear. Given the p53-like properties of p63 and p73, we tested whether they are involved in tumor suppression by aging mice heterozygous for mutations in all p53 family genes and scored for spontaneous tumors. We show here that p63+/-;p73+/- mice develop spontaneous tumors. Loss of...
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