Article
Full restoration of viral fitness by multiple compensatory co-mutations in the nucleoprotein of influenza A virus cytotoxic T-lymphocyte escape mutants.
The Journal of general virology - 1 Jun 2005
Rimmelzwaan G F, Berkhoff E G M, Nieuwkoop N J, Smith D J, Fouchier R A M, Osterhaus A D M E
Abstract excerpt
Amino acid substitutions have been identified in the influenza A virus nucleoprotein that are associated with escape from recognition by virus-specific cytotoxic T lymphocytes (CTLs). One of these is the arginine-to-glycine substitution at position 384 (R384G). This substitution alone, however, is detrimental to viral fitness, which is overcome in part by the functionally compensating co-mutation E375G. Here, the...
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