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Article

Intragenic complementation of hepatitis C virus NS5A RNA replication-defective alleles.

Journal of virology - 1 Feb 2013

Fridell Robert A, Valera Lourdes, Qiu Dike, Kirk Melissa J, Wang Chunfu, Gao Min

Abstract excerpt

Hepatitis C virus NS5A has three structural domains, is required for RNA replication and virion assembly, and exists in hypo- and hyperphosphorylated forms. Accumulated data suggest that phosphorylation is involved in modulating NS5A functions. We performed a mutational analysis of highly conserved serine residues in the linker region between domains I and II of genotype 2a JFH1 NS5A. As with genotype 1b Con1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23236071
DOI: 10.1128/JVI.02861-12
PMCID: PMC3571461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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