Overlapping cytotoxic T-lymphocyte and B-cell antigenic sites on the influenza virus H5 hemagglutinin.

doi:10.1128/JVI.64.12.6246-6251.1990

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Article

Overlapping cytotoxic T-lymphocyte and B-cell antigenic sites on the influenza virus H5 hemagglutinin.

Journal of virology - 1 Dec 1990

Hioe C E, Dybdahl-Sissoko N, Philpott M, Hinshaw V S

Abstract excerpt

To define the recognition site of cytotoxic T lymphocytes (CTLs) on influenza virus H5 hemagglutinin (HA), an H5 HA-specific CTL clone was examined for the ability to recognize monoclonal antibody-selected HA variants of influenza virus A/Turkey/Ontario/7732/66 (H5N9). On the basis of 51Cr release assays with the variants, a CTL epitope was located near residue 168 of H5 HA. To define the epitope more precisely,...

Topics

Amino Acid Sequence
Animals
B-Lymphocytes
Cell Line
Chickens
Cytotoxicity, Immunologic
Epitopes
Female
Genetic Variation
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza A virus

Mice

Mice, Inbred BALB C

Models, Molecular

Molecular Sequence Data

Mutagenesis, Site-Directed

Protein Conformation

Source

Open in PubMed Open full text

Identifiers

PMID: 1700833
DOI: 10.1128/JVI.64.12.6246-6251.1990
PMCID: PMC248799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1700833-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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