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Article

Functional compensation of a detrimental amino acid substitution in a cytotoxic-T-lymphocyte epitope of influenza a viruses by comutations.

Journal of virology - 1 Aug 2004

Rimmelzwaan G F, Berkhoff E G M, Nieuwkoop N J, Fouchier R A M, Osterhaus A D M E

Abstract excerpt

Influenza A viruses accumulate amino acid substitutions in cytotoxic-T-lymphocyte (CTL) epitopes, allowing these viruses to escape from CTL immunity. The arginine-to-glycine substitution at position 384 of the viral nucleoprotein is associated with escape from CTLs. Introduction of the R384G substitution in the nucleoprotein gene segment of influenza virus A/Hong Kong/2/68 by site-directed mutagenesis was...

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Source

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Identifiers

PMID: 15280506
DOI: 10.1128/JVI.78.16.8946-8949.2004
PMCID: PMC479054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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