Article
Genotoxicity of 15-deoxygoyazensolide in bacteria and yeast.
Mutation research - 10 Jul 2007
Vasconcellos Marne C, Rosa Renato M, Machado Miriana S, Villela Izabel V, Crotti Antônio Eduardo Miller, Lopes João Luis Callegari, Pessoa Cláudia, de Moraes Manoel Odorico, Lopes Norberto Peporine, Costa-Lotufo Letícia V, Saffi Jenifer, Henriques João Antônio Pegas
Abstract excerpt
Sesquiterpene lactones (SLs) present a wide range of pharmacological activities. The aim of our study was to investigate the genotoxicity of 15-deoxygoyazensolide using the Salmonella/microsome assay and the yeast Saccharomyces cerevisiae. We also investigated the nature of induced DNA damage using yeast strains defective in DNA repair pathways, such as nucleotide excision repair (RAD3), error prone repair...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.