Asymmetric recognition of psoralen interstrand crosslinks by the nucleotide excision repair and the error-prone repair pathways.

doi:10.1006/jmbi.1999.2550

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Article

Asymmetric recognition of psoralen interstrand crosslinks by the nucleotide excision repair and the error-prone repair pathways.

Journal of molecular biology - 12 Mar 1999

Barre F X, Asseline U, Harel-Bellan A

Abstract excerpt

Psoralen is an asymmetric photoreactive intercalator with a furane and a pyrone side. When intercalated at 5'-TpA-3' sites and upon UVA irradiation, the psoralen can react with the thymine residues on both strands, introducing an interstrand crosslink. Using psoralen-coupled triple-helix-forming oligonucleotides, psoralen interstrand crosslinks can be site-specifically introduced in the coding sequence of URA3, a...

Topics

Base Sequence
Cross-Linking Reagents
DNA
DNA Adducts
DNA Mutational Analysis
DNA Repair
DNA, Single-Stranded
Ficusin
Fungal Proteins
HIV-1
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Mutation

Oligodeoxyribonucleotides

Plasmids

Pyrones

Thymine

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 10064704
DOI: 10.1006/jmbi.1999.2550

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