Article
Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells. Unusually high sensitivity of ERCC2 and ERCC3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agents.
Biochemical pharmacology - 19 Jul 1994
Kelner M J, McMorris T C, Estes L, Rutherford M, Montoya M, Goldstein J, Samson K, Starr R, Taetle R
Abstract excerpt
Illudins, novel natural products with a structure unrelated to any other known chemical, display potent in vitro and in vivo anti-cancer activity against even multi-drug resistant tumors, and are metabolically activated to an unstable intermediate that binds to DNA. The DNA damage produced by ill...
Topics
- Animals
- Antibiotics, Antineoplastic
- Carmustine
- Cell Line
- Cisplatin
- Cricetinae
- Cricetulus
- DNA
- DNA Damage
- DNA Helicases
- DNA-Binding Proteins
- Mitomycins
- Mutation
- Polycyclic Sesquiterpenes