Article
Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.
DNA repair - 5 Dec 2002
Jaspers Nicolaas G J, Raams Anja, Kelner Michael J, Ng Jessica M Y, Yamashita Yukiko M, Takeda Shiunichi, McMorris Trevor C, Hoeijmakers Jan H J
Abstract excerpt
Illudin S is a natural sesquiterpene drug with strong anti-tumour activity. Inside cells, unstable active metabolites of illudin cause the formation of as yet poorly characterised DNA lesions. In order to identify factors involved in their repair, we have performed a detailed genetic survey of repair-defective mutants for responses to the drug. We show that 90% of illudin's lethal effects in human fibroblasts can...
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