Article
CD1A and CD1E gene polymorphisms are associated with susceptibility to multiple sclerosis.
International journal of immunopathology and pharmacology - 1 Jan 2000
Caporale C M, Notturno F, Pace M, Aureli A, Di Tommaso V, De Luca G, Farina D, Giovannini A, Uncini A
Abstract excerpt
Multiple sclerosis (MS) is thought to be an autoimmune T-cell-mediated disease directed at myelin antigens of the central nervous system. Besides myelin proteins, lipid components of CNS are supposed to play a role as antigens for T cells in MS. CD1 is a family of MHC-like glycoproteins specialized in capturing and presenting a variety of microbial and self lipids and glycolipids to antigen-specific T cells....
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