Article
Pathogenic CD8(+) T cells in multiple sclerosis.
Annals of neurology - 1 Aug 2009
Friese Manuel A, Fugger Lars
Abstract excerpt
Traditionally, autoimmune pathogeneses have been attributed to CD4(+) T lymphocytes, as in multiple sclerosis (MS), rheumatoid arthritis, type 1 diabetes mellitus, and/or to B lymphocytes, as in myasthenia gravis and systemic lupus erythematosus. That is because their primary genetic associations are mostly with certain human leukocyte antigen class II alleles, whose gene products present antigens to CD4(+) T...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- Brain
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Clinical Trials as Topic
- Cytokines
- Genes, MHC Class I
- Humans
- Models, Neurological
- Multiple Sclerosis
- Spinal Cord