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Article

PD-1/PD-L and autoimmunity: A growing relationship.

Cellular immunology - 1 Dec 2016

Zamani Mohammad Reza, Aslani Saeed, Salmaninejad Arash, Javan Mohammad Reza, Rezaei Nima

Abstract excerpt

Programmed death 1 (PD-1) and its ligands, namely PD-L1 and PD-L2, are one of the key factors responsible for inhibitory T cell signaling, mediating the mechanisms of tolerance and providing immune homeostasis. Mounting evidence demonstrates that impaired PD-1:PD-L function plays an important role in a variety of autoimmune diseases such as Type 1 diabetes (T1D), encephalomyelitis, inflammatory bowel diseases...

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Identifiers

PMID: 27660198
DOI: 10.1016/j.cellimm.2016.09.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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