Article
Variants in Intron 4 of PD-1 Gene are Associated with the Susceptibility to SLE in an Iranian Population.
Iranian journal of immunology : IJI - 1 Sept 2020
Khanjari Yousef, Oladnabi Morteza, Abdollahi Nafiseh, Heidari Ahmad, Mohammadi Saeed, Tabarraei Alijan
Abstract excerpt
BACKGROUND: Programmed cell death protein 1 (PD-1) is a negative co-stimulatory molecule with immunomodulatory properties. Recently, PD-1 gene defects have attracted attention in the pathogenesis of SLE. OBJECTIVE: Here, we assessed the association of PD-1 gene polymorphisms in intron 4 and haplotypes with the susceptibility to SLE. METHODS: Seventy-six SLE patients and 159 healthy controls were included. We...
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