Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients.

doi:10.1007/s10048-012-0316-y

Article

Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients.

Neurogenetics - 1 May 2012

Schmied Mascha C, Zehetmayer Sonja, Reindl Markus, Ehling Rainer, Bajer-Kornek Barbara, Leutmezer Fritz, Zebenholzer Karin, Hotzy Christoph, Lichtner Peter, Meitinger Thomas, Wichmann H-Erich, Illig Thomas, Gieger Christian, Huber Klaus, Khalil Michael, Fuchs Sigrid, Schmidt Helena, Auff Eduard, Kristoferitsch Wolfgang, Fazekas Franz, Berger Thomas, Vass Karl, Zimprich Alexander

Abstract excerpt

We performed a replication study in 883 Austrian multiple sclerosis (MS) patients and 972 control individuals for 25 previously risk-associated loci (39 SNPs). Two loci, rs1109670 (DDEF2/MBOAT2, p < 0.02) and rs16914086 (TBC1D2, p < 0.05), are replicated here for the first time. Furthermore, we tested all 39 SNPs for association with age at disease onset and measures of disease severity. We observed a trend for...

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Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients.

Abstract excerpt

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