Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression of the LIM domain mutants of LMO2.

Experimental hematology - 1 Jun 2005

Terano Tomo, Zhong Yi, Toyokuni Shinya, Hiai Hiroshi, Yamada Yoshihiro

Abstract excerpt

OBJECTIVE: The LIM-finger protein LMO2 forms a transcription factor complex with other hematopoietic regulator proteins, such as TAL1 (SCL), LDB1, GATA1, 2, and 3, in the promoters of several erythroid genes. To elucidate the functional role of two LIM domains in LMO2, we introduced deletion or mutation in each of the LIM domains and analyzed their phenotypic effects on the hematopoietic system when overexpressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to LIM Domain Proteins

Share to Metalloproteins

Share to Mutagenesis, Site-Directed

Share to Transcription, Genetic

Source

Identifiers

PMID: 15911088
DOI: 10.1016/j.exphem.2005.01.018

Genes

LMO2
LIM2
LDB1
TAL1
GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression of the LIM domain mutants of LMO2.PMID 15911088Read ↗

The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis.Semantic proximity Read ↗

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.Semantic proximity Read ↗

HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias.Semantic proximity Read ↗

The LMO2 oncogene regulates DNA replication in hematopoietic cellsSemantic proximity Read ↗

TheLMO2T-Cell Oncogene Is Activated via Chromosomal Translocations or Retroviral Insertion during Gene Therapy but Has No Mandatory Role in Normal T-Cell DevelopmentSemantic proximity Read ↗

LMO2 Oncoprotein Stability in T-Cell Leukemia Requires Direct LDB1 Binding.Semantic proximity Read ↗

Requirement for Lyl1 in a model of Lmo2-driven early T-cell precursor ALLSemantic proximity Read ↗

Embryonic erythropoiesis and hemoglobin switching require transcriptional repressor ETO2 to modulate chromatin organizationSemantic proximity Read ↗

Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.Semantic proximity Read ↗

Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development.Semantic proximity Read ↗

Targeting LMO2 with a Peptide Aptamer Establishes a Necessary Function in Overt T-Cell NeoplasiaSemantic proximity Read ↗

The LIM domain gene <i>LMO4</i> inhibits differentiation of mammary epithelial cells <i>in vitro</i> and is overexpressed in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.