Article
Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
Molecular and cellular biology - 1 Mar 2004
Tse E, Smith A J H, Hunt S, Lavenir I, Forster A, Warren A J, Grutz G, Foroni L, Carlton M B L, Colledge W H, Boehm T, Rabbitts T H
Abstract excerpt
The LIM-only family of proteins comprises four members; two of these (LMO1 and LMO2) are involved in human T-cell leukemia via chromosomal translocations, and LMO2 is a master regulator of hematopoiesis. We have carried out gene targeting of the other members of the LIM-only family, viz., genes Lmo1, Lmo3 and Lmo4, to investigate their role in mouse development. None of these genes has an obligatory role in...
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