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Article

HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias.

Oncogene - 28 Nov 2013

Calero-Nieto F J, Joshi A, Bonadies N, Kinston S, Chan W-I, Gudgin E, Pridans C, Landry J-R, Kikuchi J, Huntly B J, Gottgens B

Abstract excerpt

The Lim Domain Only 2 (LMO2) leukaemia oncogene encodes an LIM domain transcriptional cofactor required for early haematopoiesis. During embryogenesis, LMO2 is also expressed in developing tail and limb buds, an expression pattern we now show to be recapitulated in transgenic mice by an enhancer in LMO2 intron 4. Limb bud expression depended on a cluster of HOX binding sites, while posterior tail expression...

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Source

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Identifiers

PMID: 23708655
DOI: 10.1038/onc.2013.175
PMCID: PMC3898495

Genes

LMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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HOX-mediated LMO2 expression in embryonic mesoderm is recapitulated in acute leukaemias.PMID 23708655Read ↗

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TheLMO2T-Cell Oncogene Is Activated via Chromosomal Translocations or Retroviral Insertion during Gene Therapy but Has No Mandatory Role in Normal T-Cell DevelopmentSemantic proximity Read ↗

LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct PathwaysSemantic proximity Read ↗

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Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.Semantic proximity Read ↗

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