Article
The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function.
The Journal of biological chemistry - 18 Nov 2005
Dhar-Chowdhury Piyali, Harrell Maddison D, Han Sandra Y, Jankowska Danuta, Parachuru Lavanya, Morrissey Alison, Srivastava Shekhar, Liu Weixia, Malester Brian, Yoshida Hidetada, Coetzee William A
Abstract excerpt
The regulation of ATP-sensitive potassium (K(ATP)) channel activity is complex and a multitude of factors determine their open probability. Physiologically and pathophysiologically, the most important of these are intracellular nucleotides, with a long-recognized role for glycolytically derived ATP in regulating channel activity. To identify novel regulatory subunits of the K(ATP) channel complex, we performed a...
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