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Article

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.

Nature - 17 May 2007

Sato Masamitsu, Toda Takashi

Abstract excerpt

Microtubules are essential intracellular structures involved in several cellular phenomena, including polarity establishment and chromosome segregation. Because the nuclear envelope persists during mitosis (closed mitosis) in fission yeast (Schizosaccharomyces pombe), cytoplasmic microtubules must be reorganized into the spindle in the compartmentalized nucleus on mitotic entry. An ideal mechanism might be to...

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Identifiers

PMID: 17476213
DOI: 10.1038/nature05773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.PMID 17476213Read ↗

Crm1 is a mitotic effector of Ran-GTP in somatic cells.Semantic proximity Read ↗

Role of nucleocytoplasmic transport in interphase microtubule organization in fission yeast.Semantic proximity Read ↗

Nucleocytoplasmic shuttling of the TACC protein Mia1p/Alp7p is required for remodeling of microtubule arrays during the cell cycle.Semantic proximity Read ↗

The spindle pole bodies facilitate nuclear envelope division during closed mitosis in fission yeast.Semantic proximity Read ↗

Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation.Semantic proximity Read ↗

Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis.Semantic proximity Read ↗

Localization and role of RAP55/LSM14 in HeLa cells: a new finding on the mitotic spindle assembly.Semantic proximity Read ↗

Essential role of tubulin-folding cofactor D in microtubule assembly and its association with microtubules in fission yeast.Semantic proximity Read ↗

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.Semantic proximity Read ↗

The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint.Semantic proximity Read ↗

Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle lengthSemantic proximity Read ↗

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.Semantic proximity Read ↗

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