Article
HURP regulates chromosome congression by modulating kinesin Kif18A function.
Current biology : CB - 27 Sept 2011
Ye Fan, Tan Lora, Yang Qiaoyun, Xia Yun, Deng Lih-Wen, Murata-Hori Maki, Liou Yih-Cherng
Abstract excerpt
Chromosome biorientation and congression during mitosis require precise control of microtubule dynamics [1-4]. The dynamics of kinetochore microtubules (K-MTs) are regulated by a variety of microtubule-associated proteins (MAPs) [4-9]. Recently, a MAP known as HURP (hepatoma upregulated protein) was identified [10-12]. During mitosis, Ran-guanosine 5'-triphosphate (RanGTP) releases HURP from the importin β...
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