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Article

RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.

Journal of cell science - 1 Nov 2007

Tedeschi Antonio, Ciciarello Marilena, Mangiacasale Rosamaria, Roscioli Emanuele, Rensen Wilhelmina M, Lavia Patrizia

Abstract excerpt

The GTPase RAN has an established role in spindle assembly and in mitotic progression, although not all mechanisms are fully understood in somatic cells. Here, we have downregulated RAN-binding protein 1 (RANBP1), a RAN partner that has highest abundance in G2 and mitosis, in human cells. RANBP1-depleted cells underwent prolonged prometaphase delay often followed by apoptosis. Cells that remained viable assembled...

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Source

Identifiers

PMID: 17940066
DOI: 10.1242/jcs.009308

Genes

RANBP1
RAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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