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Article

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.

Current biology : CB - 20 Aug 2002

Moore William, Zhang Chuanmao, Clarke Paul R

Abstract excerpt

Ran GTPase is involved in several aspects of nuclear structure and function, including nucleocytoplasmic transport and nuclear envelope formation. Experiments using Xenopus egg extracts have shown that generation of Ran-GTP by the guanine nucleotide exchange factor RCC1 also plays roles in mitotic spindle assembly. Here, we have examined the localization and function of RCC1 in mitotic human cells. We show that...

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Source

Identifiers

PMID: 12194828
DOI: 10.1016/s0960-9822(02)01076-x

Genes

RCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells.PMID 12194828Read ↗

Crm1 is a mitotic effector of Ran-GTP in somatic cells.Semantic proximity Read ↗

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation.Semantic proximity Read ↗

RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.Semantic proximity Read ↗

Dynamic localisation of Ran GTPase during the cell cycle.Semantic proximity Read ↗

Ran-GTP is non-essential to activate NuMA for spindle pole focusing, but dynamically polarizes HURP to control mitotic spindle lengthSemantic proximity Read ↗

Spatial and temporal coordination of mitosis by Ran GTPase.Semantic proximity Read ↗

Tumor Cell Dependence on Ran-GTP–Directed MitosisSemantic proximity Read ↗

N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis.Semantic proximity Read ↗

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.Semantic proximity Read ↗

Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis.Semantic proximity Read ↗

Determinants of human cyclin B1 association with mitotic chromosomes.Semantic proximity Read ↗

NNF1 is an essential yeast gene required for proper spindle orientation, nucleolar and nuclear envelope structure and mRNA export.Semantic proximity Read ↗

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