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Article

Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300.

Cancer science - 1 May 2005

Masuda Shigeo, Kumano Keiki, Shimizu Kiyoshi, Imai Yoichi, Kurokawa Mineo, Ogawa Seishi, Miyagishi Makoto, Taira Kazunari, Hirai Hisamaru, Chiba Shigeru

Abstract excerpt

The Notch proteins constitute a family of transmembrane receptors that play a pivotal role in cellular differentiation, proliferation and apoptosis. Although it has been recognized that excess Notch signaling is potentially tumorigenic, little is known about precise mechanisms through which dysregulated Notch signaling induces neoplastic transformation. Here we demonstrate that Notch signaling has a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Receptor, Notch1

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Source

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Identifiers

PMID: 15904468
DOI: 10.1111/j.1349-7006.2005.00048.x
PMCID: PMC11159266

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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