Physical and Functional Interaction of SMADs and p300/CBP

doi:10.1074/jbc.273.36.22865

Article

Physical and Functional Interaction of SMADs and p300/CBP

1 Sept 1998

Abstract excerpt

SMADs are transforming growth factor beta (TGF-beta) receptor substrates and mediators of TGF-beta transcriptional responses. Here we provide evidence that the coactivators p300 and CBP interact with Smads 1 through 4. The biological relevance of this interaction is shown in vivo by overexpression of the adenovirus E1A protein and mutant forms of E1A that lack p300-binding sites. Wild-type E1A, but not the...

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