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Article

Inhibition of p300 Histone Acetyltransferase by Viral Interferon Regulatory Factor

1 Nov 2000

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus (KSHV) has been consistently identified in Kaposi's sarcomas, body cavity-based lymphomas, and some forms of Castleman's disease. The K9 open reading frame of KSHV encodes a viral interferon regulatory factor (vIRF) which functions as a repressor for cellular interferon-mediated signal transduction and as an oncogene to induce cell growth transformation. We demonstrate that...

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PMID: 11027294
DOI: 10.1128/mcb.20.21.8254-8263.2000

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