[Effect of mutation in the p300 transcription coactivator on transcriptional response and cell proliferation of human carcinoma cell lines].

doi:10.5357/koubyou.69.139

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Article

[Effect of mutation in the p300 transcription coactivator on transcriptional response and cell proliferation of human carcinoma cell lines].

Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan - 1 Jun 2002

Suganuma Tamaki

Abstract excerpt

The p300 and closely related CBP acetyltransferases function as global transcriptional coactivators and play important roles in a broad spectrum of biological processes, including cell proliferation and differentiation. The p300 protein is targeted by viral oncoproteins, and mutations of the p300 gene associated with second allele inactivation have been identified in certain types of human cancers and carcinomas....

Topics

Carcinoma
Cell Differentiation
Cell Division
DNA, Neoplasm
Humans
Mutation
Nuclear Proteins
Trans-Activators
Transcription, Genetic
Transforming Growth Factor beta
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 12136661
DOI: 10.5357/koubyou.69.139

Provenance

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