Article
Role of p300, a transcriptional coactivator, in signalling of TGF-beta.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 1998
Nishihara A, Hanai J I, Okamoto N, Yanagisawa J, Kato S, Miyazono K, Kawabata M
Abstract excerpt
BACKGROUND: Smad proteins are novel transcriptional regulators mediating the signalling of the transforming growth factor-beta (TGF-beta) superfamily. Coactivators such as p300/CBP promote transactivation by various transcription factors through a direct interaction with them. Adenoviral oncoprot...
Topics
- Adenovirus E1A Proteins
- Animals
- Binding Sites
- COS Cells
- Cricetinae
- DNA-Binding Proteins
- Luciferases
- Mutation
- Nuclear Proteins
- Receptors, Transforming Growth Factor beta
- Signal Transduction
- Smad2 Protein
- Smad3 Protein
- Trans-Activators
- Transfection
- Transforming Growth Factor beta