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Article

Role of p300, a transcriptional coactivator, in signalling of TGF-beta.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Sept 1998

Nishihara A, Hanai J I, Okamoto N, Yanagisawa J, Kato S, Miyazono K, Kawabata M

Abstract excerpt

BACKGROUND: Smad proteins are novel transcriptional regulators mediating the signalling of the transforming growth factor-beta (TGF-beta) superfamily. Coactivators such as p300/CBP promote transactivation by various transcription factors through a direct interaction with them. Adenoviral oncoprotein E1A, which binds p300, was shown to inhibit the signalling of TGF-beta. These findings raise the possibility that...

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Identifiers

PMID: 9813111
DOI: 10.1046/j.1365-2443.1998.00217.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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