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Article

TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription

19 Oct 2016

Abstract excerpt

Transforming growth factor β (TGF-β) signaling facilitates tumor development during the advanced stages of tumorigenesis, but induces cell-cycle arrest for tumor suppression during the early stages. However, the mechanism of functional switching of TGF-β is still unknown, and it is unclear whether inhibition of TGF-β signaling results amelioration or exacerbation of cancers. Here we show that the tumor suppressor...

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PMID: 27759037
DOI: 10.1038/srep35483

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