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Selectins in Biology and Human Disease: Opportunity in E-selectin Antagonism

9 Jun 2024

Abstract excerpt

Selectins are cell adhesion proteins discovered in the 1980s. As C-type lectins, selectins contain an essential calcium ion in the ligand-binding pocket and recognize the isomeric tetrasaccharides sialyl Lewisx (sLex) and sialyl Lewisa (sLea). Three selectins, E-selectin, P-selectin, and L-selectin, play distinct, complementary roles in inflammation, hematopoiesis, and tumor biology. They have been implicated in...

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PMID: 38983984
DOI: 10.7759/cureus.61996

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