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Cytochrome P450 2C8: Substrates, inhibitors, pharmacogenetics, and clinical relevance

1 May 2005

Abstract excerpt

Cytochrome P450 (CYP) 2C8 [corrected] has been a relatively neglected member of the human CYP2C family. Over the period from 2000 through 2003, PubMed searches with the key word CYP2C8 returned only 10% to 15% of the citations obtained for all of the CYP2C enzymes combined. However, in the past year a crystal structure for CYP2C8 has been described, new inhibitors and probe substrates for the enzyme have been in...

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PMID: 15900280
DOI: 10.1016/j.clpt.2004.12.267

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