Article
Cytochromes P450: decision-making tools for personalized therapeutics.
Current opinion in molecular therapeutics - 1 Dec 2006
Murray Michael, Petrovic Nenad
Abstract excerpt
The responses of patients to standard drug regimens vary widely, with dose responses ranging from subtherapeutic to toxic. The primary goal of individualized medicine is the optimization of drug therapy, which involves the selection of appropriate drugs, dosages and drug combinations, and the minimization of toxic side effects. The cytochrome P450 (CYP) enzymes mediate the oxidative biotransformation of most...
Topics
- Alleles
- Biotransformation
- Cytochrome P-450 Enzyme System
- Drug Therapy
- Genetic Variation
- Genotype
- Humans
- Pharmaceutical Preparations
- Pharmacogenetics
- Pharmacokinetics
- Phenotype