Article
The A1 allele of the human D2 dopamine receptor gene is associated with increased activity of striatal L-amino acid decarboxylase in healthy subjects.
Pharmacogenetics and genomics - 1 Jun 2005
Laakso Aki, Pohjalainen Tiina, Bergman Jörgen, Kajander Jaana, Haaparanta Merja, Solin Olof, Syvälahti Erkka, Hietala Jarmo
Abstract excerpt
The A1 allele of the TaqI restriction fragment length polymorphism (RFLP) of the human dopamine D2 receptor gene (DRD2) is associated with a low density of D2 dopamine receptors in the striatum. Because of the important role of D2 autoreceptors in regulating dopamine synthesis, we aimed to examine whether subjects with the A1 allele have altered presynaptic dopamine function in the brain. We also studied the...
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