The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers.

doi:10.1038/sj.mp.4000350

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Article

The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers.

Molecular psychiatry - 1 May 1998

Pohjalainen T, Rinne J O, Någren K, Lehikoinen P, Anttila K, Syvälahti E K, Hietala J

Abstract excerpt

Positron emission tomography (PET) studies have revealed significant interindividual variation in dopamine D2 receptor density in vivo in human striatum. Low D2 receptor binding in vivo has been found to associate with alcohol/substance dependence. It has been suggested that the A1 allele of huma...

Topics

Adult
Alleles
Brain
Brain Chemistry
Dopamine Antagonists
Dopamine D2 Receptor Antagonists
Female
Finland
Genotype
Humans
Male
Middle Aged
Polymorphism, Restriction Fragment Length
Raclopride
Radioligand Assay
Receptors, Dopamine D2
Salicylamides
Tomography, Emission-Computed

Source

Open in PubMed

Identifiers

PMID: 9672901
DOI: 10.1038/sj.mp.4000350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9672901-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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