C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo.

doi:10.1016/j.pnpbp.2009.02.021

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Article

C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo.

Progress in neuro-psychopharmacology & biological psychiatry - 15 Jun 2009

Hirvonen Mika M, Lumme Ville, Hirvonen Jussi, Pesonen Ullamari, Någren Kjell, Vahlberg Tero, Scheinin Harry, Hietala Jarmo

Abstract excerpt

The C957T (rs6277) single nucleotide polymorphism (SNP) of the human dopamine D2 receptor (DRD2) gene (DRD2) affects DRD2 mRNA stability and has been shown to predict striatal DRD2 availability (B(max)/K(D)) in vivo in man. Specifically, the C/C genotype is associated with low striatal DRD2 avail...

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PMID: 19285111
DOI: 10.1016/j.pnpbp.2009.02.021

Genes

DRD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19285111-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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