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Article

Smad1 and Smad8 function similarly in mammalian central nervous system development.

Molecular and cellular biology - 1 Jun 2005

Hester Mark, Thompson John C, Mills Joseph, Liu Ye, El-Hodiri Heithem M, Weinstein Michael

Abstract excerpt

Smads 1, 5, and 8 are the intracellular mediators for the bone morphogenetic proteins (BMPs), which play crucial roles during mammalian development. Previous research has shown that Smad1 is important in the formation of the allantois, while Smad5 has been shown to be critical in the process of angiogenesis. To further analyze the BMP-responsive Smads, we disrupted the murine Smad8 gene utilizing the Cre/loxP...

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Identifiers

PMID: 15899870
DOI: 10.1128/MCB.25.11.4683-4692.2005
PMCID: PMC1140628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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