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Article

Smad7 Is Required for the Development and Function of the Heart

25 Oct 2008

Abstract excerpt

Transforming growth factor-beta (TGF-beta) family members, including TGF-betas, activins, and bone morphogenetic proteins, exert diverse biological activities in cell proliferation, differentiation, apoptosis, embryonic development, and many other processes. These effects are largely mediated by Smad proteins. Smad7 is a negative regulator for the signaling of TGF-beta family members. Dysregulation of Smad7 is...

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PMID: 18952608
DOI: 10.1074/jbc.m807233200

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