Article
Characterization of zebrafish smad1, smad2 and smad5: the amino-terminus of smad1 and smad5 is required for specific function in the embryo.
Mechanisms of development - 1 Oct 1999
Müller F, Blader P, Rastegar S, Fischer N, Knöchel W, Strähle U
Abstract excerpt
Members of the TGFbeta superfamily of signalling molecules play important roles in mesendoderm induction and dorsoventral patterning of the vertebrate embryo. We cloned three intracellular mediators of TGFbeta signalling, smad1, 2 and 5, from the zebrafish. The three smad genes are expressed ubiquitously at the onset of gastrulation. The pattern of expression becomes progressively restricted during somitogenesis...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.