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Cerebellar Deficits and Hyperactivity in Mice Lacking Smad4

1 Oct 2003

Abstract excerpt

Smad4 is a central mediator of TGF-beta signals, which are known to play essential roles in many biological processes. Using a Cre-loxP approach to overcome early embryonic lethality, we have studied functions of TGF-beta/Smad4 signals in the central nervous system (CNS). No obvious deficits were detected in mice carrying the targeted disruption of Smad4 in the CNS. The overall morphology of the hippocampus...

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PMID: 12896967
DOI: 10.1074/jbc.m308287200

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